Dr. Siva Arunasalam, the formulator of Arginext, was one of the first researchers to demonstrate that supplemental Arginine can help improve your body’s ability to produce Nitric Oxide (N-O). In selected studies it was shown that l-aginine based supplements can help increase circulation, energy, endurance, and ability to exercise.

Dr. Siva, is board-certified in internal medicine, cardiology, and interventional cardiology. He completed his internship at the Harbor UCLA Medical Center in Torrance, CA and his fellowship in cardiology at Cedars-Sinai Medical Center in Los Angeles, CA.

In 1996, Dr. Siva founded the High Desert Heart Institute in Victorville, CA where he currently serves as the President and attending cardiologist. He and his surrounding staff of fellow cardiologists, nurses, and medical personnel are heavily involved in researching alternative, noninvasive solutions for improving heart health.[/dropshadowbox]


Can L-arginine Supplement Help?

Taking an L-arginine supplement (an essential amino acid and one of the building blocks of proteins in the body) benefits your cardiovascular health by promoting Nitric Oxide production, which is essential to optimal blood flow. L-arginine has become known as a safe and effective prosexual nutrient for men and women. 

In collaboration with medical industry and FDA, the Heart Institute is involved in cutting edge research on the effect of high quality L-arginine (the pharmaceutical grade) . The Heart Institute collaboration with a number of leading pharmaceuticals and nutritional manufacturing companies highlighted the potency of the high quality L-arginine based supplements.

Findings on the safety and efficacy of L-arginine have been presented at major medical conferences, including the American College of Cardiology, and in scientific journals such as Circulation, Vascular Medicine and the Journal of the American College of Cardiology. It was concluded that to be potent a formula should include L-citrulline and other key ingredients specifically selected help promoting optimal heart health.  

Result of Clinical Studies

The cinical trial was through A long term human clinical study at The High Desert Heart Institute (HDHI) during 2009 evaluated effect of L-arginine combined with specific vitamins supplementation which was described as “The most comprehensive human clinical study ever conducted on a nutritional supplement.”

HDHI was founded by Dr. Siva Arunasalam, who is an affiliate of Cedars-Sinai of Los Angeles and internationally respected for superior care of high-risk heart patients. On completion of a number of trials Dr. Siva Arunasalam make a final statement: “I expected a marginal improvement in the symptoms…what we ended up seeing was remarkable, positive, remodelling of the heart, positive pulmonary artery changes, pulmonary vascular changes…”

Study Overview

All 33 high-risk heart failure patients, selected for this study, had reached the end of what medical science could do for them. They were treated at maximum therapy including maximum drug levels and maximum supplemental oxygen and. At the beginning of the study 60% of selected patients were on the heart-transplant list. Later Dr. Siva Arunasalam stressed that “There was nothing else for us to try, we had tried everything with these patients”. So, the last hope was reserved for nitric oxide and vitamin D and K based supplementation.

Each patient was given two scoops of the L-arginine/L-citrulline complexer in the morning and two in the evening. To scientifically measure the effects, every patient received extensive diagnostic monitoring over 13 weeks that produced 7000 points of data.

The results of the 90 day study showed that all patients had improved dramatically their health condition and many were able to resume normal lives. The result appeared to be far more significant than anyone expected.

Some compelling results of the study:

  • Peripheral blood flow increased to the feet (an ankle reading) by 16%

  • CASP (Central Aortic Systolic Pressure) decreased by 6%

  • Pulmonary Hypertension dramatically improved

  • Systolic BP decreased by 13%

  • Diastolic BP decreased by 17%

  • 40% decrease in triglycerides

  • 8% Glucose reduction

  • 25% decrease in c-reactive proteins

  • 11% reduction in creatine levels

  • 18% increase in HDL Cholesterol

  • 35% increase in magnesium levels (even though there is no magnesium in the product) magnesium is very important in improving heart health

  • Decreases in platelets in the blood

  • 18% increase in HDL Cholesterol

  • Albumin decreased by 70%
  • Bilirubin decreased significantly

  • Vitamin D levels increased by 183%

  • Quality of life measurements significantly improved for all participants

Angelo Cici’s Case

The case of Angelo Cici was particular remarkable. On Dec 20, 2008 Angelo had a massive heart failure with simultaneous renal failure, congestive heart failure, pulmonary heart failure and a pace maker failure. From this point on he was in and out of the emergency room. “I was so weak I couldn’t even open a bottle of water by myself and I had decided, I had had enough. I told the nurses I wanted all the IV’s removed and I just wanted to go home and die.”

Angelo Cici’s testimonial is a powerful message to the world: “I was never going more than 5 days with out going back into the hospital emergency room … it’s been 6 months since I’ve been into a hospital. …I feel like I’m 40 years old again.” He left the hospital and went back home.

“I’ve been doing this type of work in critical care for well over 20 years and you see what congestive heart failure does. I have seen a dramatic, a dramatic reversal in Angelo’s symptoms.”
Dan Austin, RN: Acting as the Head Nurse in charge of the High Desert Heart Institute of Victorville, California

Benefits Offered by Arginine

The body uses arginine to produce nitric oxide; arginine-derived nitric oxide (ADNO) has been shown in studies to have a multitude of benefits to health, including:

  • relaxes arteries, helping maintain normal blood pressure, which would otherwise skyrocket when ADNO is absent.

  • keeps open coronary arteries that supply blood to the heart, preventing angina pain.

  • helps to both lower serum cholesterol and prevent the “bad” LDL cholesterol from oxidizing and becoming even worse.

  • helps prevent blood platelets from clumping together into the clots that can cause heart attack and stroke.

  • serves as a critical bullet by different immune system cells that use it to kill foreign bacteria and viruses and even shrink or destroy some cancerous tumors.

  • enhances blood flow to the penis, helping to boost erections.

  • supports the brain to encode long term memory and ensure blood flow to brain cells.

  • functions as a messenger molecule that allows nerve cells in the body and brain to communicate with each other.

  • reduces pregnancy-related hypertension, a potentially life-threatening condition for both mother and child.

  • helps regulate insulin secretion by the pancreas, thereby reducing the risk of diabetes.


The High Desert Heart Institute (HDHI) provides primary care and heart disease services to patients in the surrounding communities. HDHI is very proud of their medical care and patient services-both inpatient and outpatient. HDHI provides a complete range of diagnostic and therapeutic services for patients with heart disease, lung disease or other medical and surgical conditions. Many of these services we provide at the Institute, others may need referral to a local hospital or laboratory. Listed below are those services that are provided by the Institute or at one of our local hospitals.


 The Heart Institute collaborates with numerous pharmaceuticals and nutritional manufacturing companies providing alternative therapy for their cardiac patients.The FDA approved research is available only to selected sites in the US.  The Heart Institute is one sub-site. The Heart Institute is able to provide this cutting edge research to our patient population. The Heart Institute collaborates with numerous pharmaceuticals and nutritional manufacturing companies providing alternative therapy for our cardiac patients. Such non-conventional approach of some patients significantly impacts the quality of life. We are engaged in numerous trials looking at L-Arginine in the treatment of hypertension, pulmonary hypertension, peripheral artery disease, exercise endurance, wound healing, and in the treatment of congestive heart failure.


The High Desert Heart Institute is proud to announce that in the last 18 years we have performed over 18,000 coronary angiograms and angioplasties, over 5000 peripheral interventions, over 1200 defibrillators, over 2500 pacemakers and we have the lowest morbidity and mortality in the US.

The Institute is a training centre for other cardiologists in carotid stenting, peripheral angioplasty and AICD implantation. Our doctors all routinely are faculty presenters at major cardiac conferences.

Key Ingredients

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Niric Oxide


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Vitamin K2


  • helps to control the lung airways, allowing you to breath easier and avoid common lung disorders.

  • relaxes hypertonic sphincter muscles, preventing and healing hemorrhoids and anal fissures.

  • stimulates the body into releasing human growth hormone (HGH), a key to longevity as well as improvement in body composition by boosting lean muscle mass and bone density while decreasing fat tissue.

Source: The Arginine Solution, Fried and Merrell; Warner Books, 1999, pp. 4-5.

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